a Original cataloging agency NEU GrandLibrary

a Language code of text/sound track or separate title eng

a Classification number WL355

b Item number .A5 2012

a Personal name Harman, Ferhat.

h Medium Electronic Document

a Title An evaluation of the effectiveness of pre-ischemic hyperbaric oxygen and post-ischemic aminoguanidine in experimental cerebral ischemia

c Statement of responsibility, etc Ferhat Harman, Askin E. Hasturk, Bulent Duz, Engin Gonul, Ahmet Korkmaz

c Date of publication, distribution, etc 2012.

a Summary, etc Objective: To study the effects of pre-ischemic hyperbaric oxygen (HBO) and post-ischemic aminoguanidine (AG) on the infarct volume in permanent middle cerebral artery occlusion. Methods: This study was approved by the Animal Experiments Ethics Committee of Gulhane Military Medical Academy, Ankara, Turkey and carried out from March 2006 to August 2006. A total of 28 Sprague- Dawley rats (200-320 g) were divided into 4 groups: control (K) group (n = 7); HBO group (n = 7); HBO + AG group (n = 7); and the AG group (n = 7). All rats underwent middle cerebral artery occlusion (MCAO) by subtemporal craniectomy, and permanent ischemia was created. A 2.8 atmospheric pressure of HBO was first applied to the HBO and HBO + AG groups for 45 minutes, and occlusion was created after 2 hours. In the HBO + AG group, intraperitoneal administration of AG hemisulfate (100 mg/kg) was started 6 hours after MCAO, and was continued twice a day for 3 days. Results: The rate of infarction was found to be 22.2±3.1% in the control group, 16.1±2.7% in the HBO group, 15.2±1.9% in the HBO+AG group, and 14.4±3.3% in the AG groups. The rate of infarctions (therefore the volume of infarct) in the HBO, HBO + AG, and AG groups were found to be significantly decreased compared with the control group (p=0.002, p=0.001, and p=0.001). Conclusion: In permanent MCAO-induced ischemia in rats, HBO and AG were observed to have a lowering effect on the infarct volume, but no additive effect was observed. This situation can be explained by different mechanisms of action.

a Topical term or geographic name as entry element Near East University Article

a Topical term or geographic name as entry element Yakın Doğu Üniversitesi Makale

g Relationship information 2012, Vol. 17 (2)

t Title Neurosciences